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Journal Publications Heading link


Zheng, J.; Wu, Y.-C.; Cai, X.; Phan, P.; Er, E.E.; Zhao, Z.; Lee, S. S.-Y., “Correlative multiscale 3D imaging of mouse primary and metastatic tumors by sequential light sheet and confocal fluorescence microscopy”, bioRxiv 2024, doi:

Zheng, J.; Wu, Y.-C.; Phillips, E.H.; Wang, X.; Lee, S. S.-Y., “Increased multiplexity in optical tissue clearing-based 3D immunofluorescence microscopy of the tumor microenvironment by LED photobleaching”, Laboratory Investigation 2024, 104(6), 102072.


Phillips, E.H.; Bindokas, V.P.; Jung, D.; Teamer, J.; Kitajewski, J.; Solaro, R.J.; Wolska, B.M.; Lee, S. S.-Y., “Three-dimensional spatial quantitative analysis of cardiac lymphatics in the mouse heart”, Microcirculation 2023, e12826; doi: 10.1111/micc.12826.

Wu, Y.-C.; Moon, H.-G.; Bindokas V.P.; Phillips, E.H.; Park, G.Y.; Lee, S. S.-Y., “Multi-resolution 3D optical mapping of immune cell infiltrates in mouse asthmatic lung”, American Journal of Respiratory Cell and Molecular Biology (Cover) 2023, 69 (1), 13; doi: 10.1165/rcmb.2022-0353MA.

Moon, H.-G.; Kim, S.-J.; Kim, Y.-M.; Rehman, J.; Lee, H.; Wu, Y.-C.; Lee, S. S.-Y.; Christman, J.W.; Ackerman, S.J.; Kim, M.; You, S.; Park, G.Y., “CX3CR1+ macrophage facilitates the resolution of allergic lung inflammation via interacting CCL26”, American Journal of Respiratory and Critical Care Medicine 2023; 207 (11); 1451; doi: 10.1164/rccm.202209-1670OC.

Wang, X.; Emery, S.C.; Iyer, M.A.; Szmeler, A.H.; Eddington, D.T.; Lee, S. S.-Y., “Spatially selective cell treatment and collection for integrative drug testing using hydrodynamic flow focusing and shifting”, PLOS ONE 2023; 17; e0279102.


Qiao, G.; Kone, L.; Phillips, E.H.; Lee, S. S.-Y.; Brown, G.; Khetani, S.; Thakur, A.; Lum, L.G.; Prabhakar, B.S.; Maker, A.V., “LIGHT enhanced bispecific antibody armed T-cells to treat immunotherapy resistant colon cancer”, Oncogene 2022; 41; 2054.


Efimova, E.V.; Appelbe, O.K.; Ricco, N.; Lee, S. S.-Y.; Liu, Y.; Wolfgeher D.J.; Collins, T.; Flor, A.C.; Ramamurthy, A.; Warrington S.; Bindokas, V.P.; Kron, S.J., “O-GlcNAcylation enhances double strand break repair, promotes cancer cell proliferation and prevents therapy-induced senescence in irradiated tumors”, Molecular Cancer Research 2019; pii: molcanres.1025.2018; doi: 10.1158/1541-7786.MCR-18-1025.

Ishihara, J.; Ishihara, A.; Sasaki, K.; Lee, S. S.-Y.; Yasui, M.; Abe, H.; Potin, L; Hosseinchi, P.; Fukunaga, K.; Raczy M.M.; Gray, L.T.; Williford, J.-M.; Fukayama, M.; Kron, S.J.; Swartz, M.A.; Hubbell, J.A., “Targeted antibody and cytokine cancer immunotherapies through collagen affinity”, Science Translational Medicine 2019; 11(487); pii: eaau3259; doi: 10.1126/scitranslmed.aau3259.

Karginova, O.; Weekley, C.M.; Raoul, A; Alsayed, A.; Wu, T.; Lee, S. S.-Y.; He, C.; Olopade, I.O., “Inhibition of copper transport induces apoptosis in triple negative breast cancer cells and suppresses tumor angiogenesis”, Molecular Cancer Therapeutics 2019; pii: molcanther.0667.2018. doi: 10.1158/1535-7163.MCT-18-0667.


Xu, J.; Lee, S. S.-Y.; Seo, H.; Pang, L.; Jun, Y.; Zhang, R.-Y.; Zhang, Z.-Y.; Kim, P.; Lee, W.; Kron, S.J.; Yeo, Y., “Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins”, Small 2018; 14; e1803601.

Lee, S. S.-Y.; Bindokas, V.; Lingen, M.; Kron, S.J., “Non-destructive, multiplex three-dimensional mapping of immune infiltrates in core needle biopsy”, Laboratory Investigation 2018; doi: 10/1038/s41374-018-0156-y.

Lee, S. S.-Y.; Bindokas, V.; Kron, S.J., “Multiplex three-dimensional mapping of macromolecular drug distribution in the tumor microenvironment”, Molecular Cancer Therapeutics 2018; 18; 213.

Fowler, J.L,; Lee, S. S.-Y.; Wesner, Z.C.; Olehnik, S.K.; Kron, S.J.; Hara, M., “Three-dimensional analysis of the human pancreas”, Endocrinology 2018; 159; 1393.


Lee, S. S.-Y.; Bindokas, V.; Kron, S.J., “Multiplex three-dimensional optical mapping of tumor immune microenvironment”, Scientific Reports 2017; 7; 17031.


Li, J.; Gu, D.; Lee, S. S.-Y.; Song, B.; Bandyopadhyay, S.; Chen, S.; Konieczny, S.F.; Ratliff, T.L.; Xie, J.; Cheng, J.-X., “Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer”, Oncogene 2016; 35; 6378.


Lee, S. S.-Y.*; Li, J.*; Tai, J. N.; Ratliff, T.L.; Park, K.; Cheng, J.-X., “Avasimibe encapsulated in human serum albumin blocks cholesterol esterification for selective cancer treatment”, ACS Nano 2015; 9; 2420.

Liao, C.-S.; Slipchenko, M.N.; Wang, P.; Li, J.; Lee, S.-Y.; Oglesbee, R.A.; Cheng, J.-X., “Microsecond time-scale vibrational spectral imaging by parallel detection of stimulated Raman scattering”, Light: Science & Applications 2015; 4; e265.


Ping, X.; Jiang, K.; Lee, S.-Y.; Cheng, J.-X.; Jin, X., “PEG-PDLLA micelles improve the function of myelinated axons following traumatic brain injury”, J. Neurotrauma 2014; 31; 1172.

Yue, S.; Li, J.; Lee, S.-Y.; Lee, H.J.; Shao, T.; Song, B.; Masterson, T.A.; Liu, X.; Ratliff, T.L.; Cheng, J.-X., “Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness”, Cell Metab. 2014; 19; 393.

Wu, W.*; Lee, S.-Y.*; Wu, X.; Tyler, Y.J.; Wang, H.; Ouyang, Z; Park, K.; Xu, X.-M.; Cheng, J.-X., “Neuroprotective ferulic acid (FA)-glycol chitosan (GC) nanoparticles for functional restoration of traumatically injured spinal cord”, Biomaterials 2014; 35; 2355.


Lee, S.-Y.; Jacqueline, J.T.; Kim, S.; Park, K.; Cheng, J.-X., “FRET imaging reveals different entry routes of self-assembled and disulfide bonded polymeric micelles”, Mol. Pharm. 2013; 10; 3497.

Lee, S.-Y.; Kim, S.; Jacqueline, J.T.; Park, K.; Cheng, J.-X., “Blood-stable, tumor-adaptable disulfide bonded mPEG-(Cys)(4)-PDLLA micelles for chemotherapy”, Biomaterials 2013; 34; 552.


Na, J.H.*; Lee, S.-Y.*; Lee, S.; Koo, H.; Min, K.H.; Jeong, S.Y.; Yuk, S.H.; Kim, K.; Kwon, I.C., “Effect of the stability and deformability of self-assembled glycol chitosan nanoparticles on tumor-targeting efficiency”, J. Controlled Release 2012; 163; 2.

Lee, S.J.; Huh, M.S.; Lee, S.-Y.; Min, S.; Lee, S.; Koo, H.; Jeon, H.; Choi, Y.; Choi, K.; Byun, Y.; Jeong, S.Y.; Park, K.; Kim, K.; Kwon, I.C., “Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment”, Angew. Chem. Int. Ed. 2012; 51; 7203.

Lee, S.; Lee, S.-Y.; Park, S.; Rye, J.H.; Na, J.H.; Koo, H.; Lee, K.E.; Jeon, H.; Kwon, I.C.; Kim, K.; Jeong, S.Y., “In vivo NIRF imaging of tumor targetability of nanosized liposomes in tumor-bearing mice”, Macromol. Biosci. 2012; 12; 849.


Kim, J.Y.; Choi, W.I.; Kim, Y.-H.; Tae, G.; Lee, S.-Y.; Kim, K.; Kwon, I.C., “In-vivo tumor targeting of Pluronic-based nano-carriers”, J. Controlled Release 2010; 147; 109.

Nam, T.; Park, S.; Lee, S.-Y.; Park, K.; Choi, K.; Song, I. C.; Han, M. H.; Leary, J. J.; Yuk, S. A.; Kwon, I. C.; Kim, K.; Jeong, S. Y., “Tumor targeting chitosan nanoparticles for dual-modality optical/MR cancer imaging”, Bioconjugate Chem. 2010; 21; 578.

Huh, M. S.*; Lee, S.-Y.*; Park, S.; Lee, S.; Chung, H.; Lee, S.; Choi, Y.; Oh, Y.-K.; Park, J. H.; Jeong, S. Y.; Choi, K.; Kim, K.; Kwon, I. C., “Tumor-homing glycol chitosan/polyethylenimine nanoparticles for the systemic delivery of siRNA in tumor-bearing mice”, J. Controlled Release 2010; 144; 134.

Chung, Y.-I.; Kim, J. C.; Kim, Y. H.; Tae, G.; Lee, S.-Y.; Kim, K.; Kwon, I. C., “The effect of surface functionalization of PLGA nanoparticles by heparin- or chitosan-conjugated Pluornic on tumor targeting”, J. Controlled Release 2010; 143; 374.

Lee, S.-Y.; Huh, M. S.; Lee, S. J.; Chung, H.; Park, J. H.; Oh, Y.-K.; Choi, K.; Kim, K.; Kwon, I. C., “Stability and cellular uptake of polymerized siRNA (poly-siRNA)/polyethylenimine (PEI) complexes for efficient gene silencing”, J. Controlled Release 2010; 141; 339.

Lee, S.-Y.; Tae, G.; Kim, Y.-H., “Accelerated micellization and aggregation of Pluronic micelles by the interaction with heparin”, J. Biomater. Sci. Polym. Ed. 2010; 21; 727.


Lee, S.; Ryu, J. H.; Park, K.; Lee, A.; Lee, S.-Y.; Youn, I.-C.; Ahn, C.-H.; Yoon, S. M.; Myung, S.-J.; Moon, D. H.; Chen, X.; Choi, K.; Kwon, I. C.; Kim, K., “Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo”, Nano Lett. 2009; 9; 4412.

Lee, S.-Y.; Lee, S.; Youn, I.-C.; Yi, D. K.; Lim, Y. T.; Chung, B. H.; Leary, J. F.; Kwon, I. C.; Kim, K.; Choi, K., “A near-infrared fluorescence-based optical thermosensor”, Chem. Eur. J. 2009; 15; 6103.

Nam, H. Y.; Kwon, S. M.; Chung, H.; Lee, S.-Y.; Jeon, H.; Kown, S.-H.; Her, S.; Park, J. H.; Kim, J.; Oh, Y.-K.; Kim, K.; Kwon, I. C.; Jeong, S. Y., “Cellular uptake mechanism and intracellular fate of hydrophobically modified glycol chitosan nanoparticles”, J. Controlled Release 2009; 135; 259.

Lee, S.; Park, K.; Lee, S.-Y.; Ryu, J. H.; Park, J. W.; Ahn, H. J.; Kwon, I. C.; Youn, I.-C.; Kim, K.; Choi, K., “Dark quenched matrix metalloproteinase fluorogenic probe for imaging osteoarthritis development in vivo”, Bioconjugate Chem. 2008; 19; 1743 (cover).

Lee, S.; Cha, E.-J.; Park, K.; Lee, S.-Y.; Hong, J.-K.; Sun, I.-C.; Kim, S. Y.; Choi, K.; Kwon, I. C.; Kim, K.; Ahn, C.-H., “A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination”, Angew. Chem. Int. Ed. 2008; 47; 2804


Lee, S.-Y.; Tae, G., “Formulation and in vitro characterization of an in situ gelable, photo-polymerizable Pluronic hydrogel suitable for injection”, J. Controlled Release 2007;119; 313.

Chung, Y.-I.; Ahn, K.-M.; Jeon, S.-H.; Lee, S.-Y.; Lee, J.-H.; Tae, G., “Enhanced bone regeneration with BMP-2 loaded functional nanoparticle-hydrogel complex”, J. Controlled Release 2007; 121; 91.


Chung, Y.-I.; Lee, S.-Y.; Tae, G., “The effect of heparin on the gellation of Pluronic F-127 hydrogel”, Colloids Surf. A 2006; 284; 480.

Book Chapters Heading link

Lee, S.-Y.; Cheng, J.-X., “Nanoparticulate drug delivery: clearance of nanoparticles during circulation” John Wiley & Sons, Inc. (2013), ISBN: 978-1-118-57051-7.

Phillips, E. H.; Scholten, D.; Kron, S. J.; Lee, S. S.-Y., “Multiplexed tissue tomography” Springer Science Business Media, LLC, (2021), ISBN: 978-1-0716-1592-8, pp77-93.

Wu, Y.-C.; Pagacz, J.; Emery, S.C.; Kron, S.J.; Lee, S. S.-Y., “Spatial mapping of the tumor immune microenvironment” Academic Press, (2021), ISBN: 978-0-323-90949-5, pp293-329.

Patents Heading link

Tae, G.; Lee, S.-Y., “Injectable photo-crosslinked hydrogels, biodegradable implant and drug delivery system using the same, and the preparation method thereof”, KR 10-20070776297B1.

Kim, K.; Kwon, I. C.; Choi, K.; Huh, M. S.; Lee, S.-Y.; Lee, S. J., “Polymeric nano-particles for siRNA delivery using charge interaction and covalent bonding” KR2010-0089081, US 2012/0065242.

Lee, S.-Y.; Kwon, I. C.; Kim, K.; Choi, K.; Lee, S., “SiRNA delivery system using self-assembled polymeric nanoparticles” WO2010/131907, PCT/KR2010/003013.

Kim, K.; Kwon, I. C.; Choi, K.; Lee, S.-Y.; Youn, I.; Huh, M. S.; Lee, S. J., “Method for polymerizing a small oligonucleotide, and use of a high-molecular oligonucleotide prepared by the polymerization method”, KR10-2010-0123195A, CN102361882A, US2011/0274930A1, WO2010/131835A2, EP2431378A2.

Cheng, J.-X.; Lee, S.-Y., “Cholesteryl ester-depleting nanomedicine for non-toxic cancer chemotherapy”, US20160199497 A1.