Research Project
Combination Immunotherapy Studies
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Combination immunotherapy study description
- Principal Investigator
- Lee, Steve Seung-Young
Abstract
Evan is exploring the efficacy of combining anti-PD-L1 antibody therapy (a form of immunotherapy) with other targeted therapies like anti-angiogenic drugs. While immunotherapeutic agents, such as anti-PD-L1 antibody, present promise for breast cancer and other solid tumors, clinical trials have demonstrated low or modest response rates. An immunosuppressive or unreachable tumor microenvironment may explain these results. By harnessing multiplex 3D immunofluorescence (i.e. transparent tissue tomography, T3), he aims to assess the tumor microenvironment in preclinical tumor models.